Univ. Prof. Dr. Frank Rösch

 

 

Name: Frank Rösch
Adress: Institute of Nuclear Chemistry;
Fritz-Strassmann-Weg 2
Johannes Gutenberg-University Mainz,
D-55128 Mainz, Germany
Phone:    06131-392 5302
Fax    :    06131-392 4692
@: 

 

 

 

Education and Training
1955 born in Chemnitz; Germany, 15.10.1955
1961-1974 school in Hoyerswerda, Germany
1976-1981 Studying chemistry: Technical University (TU) Dresden, Germany
1980-1981 Dipl.-Chem. TU Dresden, Faculty of Chemistry, Section Radiochemistry:
Production of  211At and investigations on cationic species of astatine and  their reactions
1981-1984 TU Dresden, Faculty of Chemistry, Section Radiochemistry:
1984 Ph.D. (Dr. rer. nat.): Faculty for Mathematics and Sciences, TU Dresden:
On the Chemistry of At(I)-Complex formations
1984-1987 Research fellow: Joint Institute for Nuclear Research, Dubna, Sowjet Union,
Laboratory for Nuclear Problems
1987-1991 Central Research Institute of the Academy of Sciences (ZfK) Rossendorf ,
Department of Radioactive Isotopes – Nuclear Pharmaca II
1988 Dissertation (Dr.sc.nat.): Faculty for Mathematics and Sciences, TU Dresden:
Basics and perspectives of the continuous electromigration measurement of  -emitting radionuclides in homogeneous aqueous electrolytes free of supporting materials
1989-1991 “Privatdozent” TU Dresden; Teaching Postgradual Radiochemistry
1992-1995
Institute of Nuclear Chemistry; Research Centre Jülich GmbH, Germany
   
Present Positions
since 1996 Professor (C4) for Nuclear Chemistry, Institute of Nuclear Chemistry,
Johannes Gutenberg-University Mainz, Germany
since 1997 Speaker of the Interdisciplinary Network of PET research
of the Johannes Gutenberg-University Mainz, Germany
since 2000 Speaker of the Centre of Competency on  PET-research
of the state of Rheinland-Pfalz, Germany
since 2000 Co-ordinator, working groub leader or vice-chair of various COST actions
(EUROPEAN COOPERATION IN SCIENCE AND TECHNOLOGY)
related to radiometals and their medical application:
D18: LANTHANIDE CHEMISTRY FOR DIAGNOSIS AND THERAPY,
D38: METAL-BASED SYSTEMS FOR MOLECULAR IMAGING APPLICATIONS
BMC0607: FROM DOSIMETRY TO BIOLOGICAL EFFECT: RADIOBIOLOGY AS GUIDE TO CLINICAL PRACTICE IN NUCLEAR MEDICINETD1004: THERAGNOSTICS IMAGING AND THERAPY: AN ACTION TO DEVELOP NOVEL NANOSIZED SYSTEMS FOR IMAGING-GUIDED DRUG DELIVERY
since 2000 Member of the working group Radiopharmaceuticals of the  
The Federal Institute for Drugs and Medical Devices
(Bundesinstitut für Arzneimittel und Medizinprodukte, Germany)
since 2001 Co-ordinator of the International Student Exchange Program for Nuclear Chemistry  / Radiopharmaceutical Chemistry between the University Mainz and the Brookhaven National Laboratory, USA
since 2003
2006-2009
2012-2015
Expert of the IAEA (International Atomic Energy Agency, Vienna)
Managing director of the Institute of Nuclear Chemistry
Managing director of the Institute of Nuclear Chemistry
   
Scientific publications and books
 
papers
since 1984 ca. 300 in peer-review journals
   
book chapters
1999 Hamkens H, Rösch F.
FDG: Biochemisches Konzept und radiochemische Synthese.
In: HJ Wieler (ed.), PET in der klinischen Onkologie,
Steinkopff Verlag, Darmstadt, 59-70
1999 Rösch F.
Aktuelle Entwicklungen 18F-markierter onkologischer PET-Tracer.
In: HJ Wieler (ed.), PET in der klinischen Onkologie,
Steinkopff Verlag, Darmstadt, 71-84
1999 Stolz B, Bruns C, Albert R, Rösch F, Smith-Jones P, Raulf F, Hoyer D, Weckbecker G.
Somatostatin receptor-targeted radiotherapy – preclinical proof of concept.
In: Octreotide: The Next Decade,
Ed S W J Lamberts, BioScientifica Ltd. (1999) pp 1-
2000 Rösch F, Wester HJ, Degrado T.R.
Current developments of 18F-labeled PET-tracers in oncology.
In: Wieler HJ, Coleman RE(eds.), PET in Clinical Oncology,
Steinkopff, Darmstadt, 55-66
2000 Hamkens H, Rösch F.
FDG: Biochemical concept and radiochemical synthesis.
In: Wieler HJ, Coleman RE (eds.), PET in Clinical Oncology,
Steinkopff, Darmstadt, 67-78
2003 Novgorodov AF, Rösch F, Korolev NA.
Radiochemical Separations by Thermochromatography.
in A Vértes, S Nagy, Z Klencsár (eds.), Handbook of Nuclear Chemistry –
Vol. 5, pp 227-259, 2003, Kluwer Academic Publishers, The Netherlands
2003 Rösch F, Knapp FF (Russ).
Radionuclide Generators.
in A Vértes, S Nagy, Z Klencsár, F Rösch (eds.), Handbook of Nuclear Chemistry –
Vol. 4, pp 81-118, 2003, Kluwer Academic Publishers, The Netherlands
2004 Rösch F, Forsell-Aronsson E.
Radio-lanthanides in Nuclear Medicine.
In: Metal Ions and Their Complexes in Medication, A. Sigel, H. Sigel, Eds.
Vol. 42. pp. 77-108,
M. Dekker, Inc., New York / Basel
2006 Rösch F, Knapp FF.
Radionuclide Generators.
In: Vértes A, Nagy S, Klencsár Z, Lovas RG, Rösch F (eds.):
Handbook of Nuclear Chemistry, Second edition,
Vol. 4, pp 1935-1976, Springer, Berlin / Heidelberg
2006 Novgorodov AF, Rösch F, Korolev NA.
Radiochemical separations by thermochromatography.
In: Vértes A, Nagy S, Klencsár Z, Lovas RG, Rösch F (eds.):
Handbook of Nuclear Chemistry, Second edition,
Vol. 5, pp 2429-2458,Springer, Berlin / Heidelberg
2006 Rösch F, Gründer G, Schreckenberger M, Dannhardt G.
Radiopharmazeutische Entwicklungen für die Molekulare Bildgebung von Prozessen im Zentralen Nervensystem.
Healthy Academy 01/2006, pp. 38-53.
in: Molecular Imaging. Innovationen und Visionen in der medizinischen Bildgebung. Herausgeber: W Niederlag, H U Lemke, W Semmler, C Bremer.
2008 Rösch F.
Radiochemistry and Radiopharmaceutical Chemistry for Medicine.
In: Encyclopedia of Life Support Systems,
EOLSS Publishers Co Ltd, Oxford , UK
2010 Rösch F, Filosofov DV.
Production, radiochemical processing and quality evaluation of Ge-68,
In: IAEA-TEC-DOC Radioisotopes and radiopharmaceuticals, Series 2: Production of Long Lived Parent Radionuclides for Generators: 68Ge, 82Sr, 90Sr and 188W,
International Atomic Energy Agency, Vienna. ISSN 2077–6462; no. 2, STI/PUB/1436,
ISBN 978–92–0–101110–7.
2011 Rösch F, Piel M.
Radiochemie / tracer.
In: Mohnike W, Hör G, Schelbert H (eds.),
PET/CT-Atlas: Interdisziplinäre onkologische, neurologische und kardiologische PET/CT-Diagnostik,
2. edition, Springer, Berlin / Heidelberg, pp. 35-72.
2012 Piel M, Rösch F.
Generator-based radiopharmaceuticals for PET dosimetry before, during, and after endoradiotherapy.
In: G Gründer (ed.) Molecular imaging in the clinical neurosciences.
Humana Press / Springer, New York / Heidelberg / Dordrecht / London, pp. 83-94.
2014 Rösch F, Baum RP.
Radiopharmaceutical chemistry.
In: Baum RP (ed.) Therapeutic Nuclear Medicine.
Springer, New York  /Heidelberg / Dordrecht / London, pp. 41-73.
   
Awards
1986 Scientific Award of the Technical University Dresden
1988 Scientific Award of the Central Research Institute of the Academy of Sciences (ZfK) Rossendorf
2006 Prize for Invention: Investitions- und Strukturbank Rheinland-Pfalz
2010 Prize for Invention: Investitions- und Strukturbank Rheinland-Pfalz
2015 Invited Speaker to the Australian and New Zeeland Society of Nuclear Medicine
2015 VIKRAM SARAHBAI oration of the Society of Nuclear Medicine, India
   
Main scientific achievements
1992-1994 Invention and introduction of the positron emitter 94mTc
1994-1997 Invention and introduction of the positron emitter 86Y and its first use as
THERANOSTICS vs. 90Y-anlogue therapeuticals
2000 Invention of the production pathway of carrier-free 177Lu via the 176Yb-route
2004 Establishment of the cation exchange-based 68Ge/68Ga radionuclide generator processing
2004 Invention and introduction of the 44Ti/Sc Generator
2006-2009 Transfer of 68Ge/68Ga generator technologies and medical applications to:
Bad Berka (Germany),
New Delhi (India),
Santiago (Chile),
Melbourne, Freemantle and Sydney (Australia)
since 2007 Organisation of several international Training schools on PET-radionuclide generators for trivalent metals: 68Ge/68Ga and 44Ti/44Sc at Mainz and elsewhere
2011 Together with Prof. Richard Baum initiator and coordinator of a series of World
Congresses on Gallium-68 and Peptide Receptor RadioNuclide Therapy (PRRNT):
1st World Congress: Bad Berka, Germany, June 23-26, 2011
2011-now Invention and introduction of a new class of radiolabeled bisphosphonates for imaging and therapy of bone metastases
2014 Publication of a teaching book for bachelor students and professionals working with radioactivity, including nuclear medicine:
Rösch F: Nuclear and Radiochemistry. Volume I: Introduction.
Walter De Gruyter, Berlin/Boston
   
Patents
since 1984 More than 30 national and international patents
   
Research
from basic inorganic radiochemistry
and physic-chemistry of of radio-metals in aqueous solutions
to production of radionuclides at cyclotrons and reactors
(such as. e.g. suggesting the positron emitters 86Y and 94mTc
or creating the pathway of nca. 177Lu via the 169Yb(n,g) route)
including measurements of nuclear data and development of radiochemical separation methods
and design of various radionuclide generator systems
(recently the post-processing of the 68Ge/68Ga-system
or the realization of the 44Ti/44Sc generator)
plus Synthesis of new radiopharmaceuticals for theranostics,
but also 18F-labelled tracers for neuro research
   
Training and Teaching
since 1987 Teaching nuclear and radiochemistry and radiopharmaceutical chemistry at the
Universities of Dresden, Cologne and Mainz
since 1990 Supervising Diploma, Bachelor and Master students from various countries (more than 50)
since 1994 Supervising PhD students from various countries (more than 30)
design of various radionuclide generator systems (recently the post-processing of the 68Ge/68Ga-system or the realization of the 44Ti/44Sc generator)
since 2006 Member of various CRP projects of the IAEA, a United Nations Organisation
since 2010 International expert of the IAEA, a United Nations Organisation, with missions to several countries
2003 and 2001
(second edition)
Publication of a scientific book for professionals working with radioactivity:
Vértes A, Nagy S, Klencsár Z, Lovas RG, Rösch F (eds.),
Handbook of Nuclear Chemistry. Second edition,
3324 p., 6 Volumes, Springer, Berlin-Heidelberg
2014 Publication of a teaching book for bachelor students and professionals working with
radioactivity, including nuclear medicine:
Rösch F: Nuclear and Radiochemistry. Volume I: Introduction.
Walter De Gruyter, Berlin/Boston
2016 Publication of a teaching book for bachelor students and professionals working with
radioactivity, including nuclear medicine:
Rösch F: Nuclear and Radiochemistry. Volume II: Modern applications of nuclear Chemistry.
Walter De Gruyter, Berlin/Boston